Citrus Aurantium Extract, Diosmin

Product: nature ep diosmin 90% powder

CAS NO.: 520-27-4

EINECS: 208-289-7

MF: C28H32O15

MW: 608.54

Botanical source:  Citrus fruits

Assay: 90%~102% (by HPLC)

Standard: EP8.3

Appearance: Greyish-yellow hygroscopic powder

Description:

Diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources or derived from the flavonoid hesperidin. Diosmin was first isolated in 1925 from Scrophularia nodosa, and first introduced as a therapeutic agent in 1969. Diosmin is a biogenic amine derived by extracting hesperidin from Citrus Aurantium L., followed by conversion of hesperidin to diosmin. Diosmin is considered to be a vascular-protecting agent used to treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. As a flavonoid, diosmin also exhibits anti-inflammatory, free-radical scavenging, and antimutagenic properties. Diosmin has been used for more than 30 years as a phlebotomic and vascular protecting agent, and has recently begun to be investigated for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.

Diosmin is an anti-inflammatory and a flavonoid glycoside that reduces venous hyper pressure.

Diosmin also reduces capillary hyperpermeability and expression of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in cells.

Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States and the rest of Europe.

Diosmin is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage) in the eye or gums. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery, and to protect against liver toxicity. It is often taken in combination with hesperidin, another plant chemical.

Function:

1. Diosmin Extract contributes to the integrity of the blood vessels. 

2. Diosmin Extract reduced cholesterol and blood pressure in rats. 

3. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss. 

4. Another animal study showed protective effects against sepsis. 

5. Diosmin Extract has anti-inflammatory effects. 

6. Diosmin Extract is also a potential sedative.

Application:

1. To help treat hemorrhoids by reducing swelling (inflammation).

2. To restore normal vein function.